Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor

The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds would disrupt normal receptor function. We used a cell-based human FXR β-lactamase (Bla) reporter gen...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Hsu, Chia-Wen, Zhao, Jinghua, Huang, Ruili, Hsieh, Jui-Hua, Hamm, Jon, Chang, Xiaoqing, Houck, Keith, Xia, Menghang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2014
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894417/
https://ncbi.nlm.nih.gov/pubmed/25257666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06437
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