A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

Essential gene functions underpin the core reactions required for cell viability, but their contributions and relationships are poorly studied in vivo. Using CRISPR interference, we created knockdowns of every essential gene in Bacillus subtilis and probed their phenotypes. Our high-confidence essen...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Peters, Jason M., Colavin, Alexandre, Shi, Handuo, Czarny, Tomasz L., Larson, Matthew H., Wong, Spencer, Hawkins, John S., Lu, Candy H. S., Koo, Byoung-Mo, Marta, Elizabeth, Shiver, Anthony L., Whitehead, Evan H., Weissman, Jonathan S., Brown, Eric D., Qi, Lei S., Huang, Kerwyn Casey, Gross, Carol A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894308/
https://ncbi.nlm.nih.gov/pubmed/27238023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.003
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