A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

Essential gene functions underpin the core reactions required for cell viability, but their contributions and relationships are poorly studied in vivo. Using CRISPR interference, we created knockdowns of every essential gene in Bacillus subtilis and probed their phenotypes. Our high-confidence essen...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Peters, Jason M., Colavin, Alexandre, Shi, Handuo, Czarny, Tomasz L., Larson, Matthew H., Wong, Spencer, Hawkins, John S., Lu, Candy H. S., Koo, Byoung-Mo, Marta, Elizabeth, Shiver, Anthony L., Whitehead, Evan H., Weissman, Jonathan S., Brown, Eric D., Qi, Lei S., Huang, Kerwyn Casey, Gross, Carol A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894308/
https://ncbi.nlm.nih.gov/pubmed/27238023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.003
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