BRD4 connects enhancer remodeling to senescence immune surveillance

Oncogene-induced senescence is a potent barrier to tumorigenesis that limits cellular expansion following certain oncogenic events. Senescent cells display a repressive chromatin configuration thought to stably silence proliferation-promoting genes, while simultaneously activating an unusual form of...

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Pubblicato in:Cancer Discov
Autori principali: Tasdemir, Nilgun, Banito, Ana, Roe, Jae-Seok, Alonso-Curbelo, Direna, Camiolo, Matthew, Tschaharganeh, Darjus F., Huang, Chun-Hao, Aksoy, Ozlem, Bolden, Jessica E., Chen, Chi-Chao, Fennell, Myles, Thapar, Vishal, Chicas, Agustin, Vakoc, Christopher R., Lowe, Scott W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893996/
https://ncbi.nlm.nih.gov/pubmed/27099234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0217
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