Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma

Inhibition of both the de novo (DNP) and salvage (NSP) pathways of nucleoside synthesis has been demonstrated to impair leukemia cells. We endeavored to determine if this approach would be efficacious in glioblastoma (GBM). To diminish nucleoside biosynthesis, we utilized compound DI-39 that selecti...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Ther
Asıl Yazarlar: Laks, Dan R, Ta, Lisa, Crisman, Thomas J, Gao, Fuying, Coppola, Giovanni, Radu, Caius G, Nathanson, David A, Kornblum, Harley I
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893966/
https://ncbi.nlm.nih.gov/pubmed/27196770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0982
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