Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma

Inhibition of both the de novo (DNP) and salvage (NSP) pathways of nucleoside synthesis has been demonstrated to impair leukemia cells. We endeavored to determine if this approach would be efficacious in glioblastoma (GBM). To diminish nucleoside biosynthesis, we utilized compound DI-39 that selecti...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Mol Cancer Ther
Autors principals: Laks, Dan R, Ta, Lisa, Crisman, Thomas J, Gao, Fuying, Coppola, Giovanni, Radu, Caius G, Nathanson, David A, Kornblum, Harley I
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893966/
https://ncbi.nlm.nih.gov/pubmed/27196770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0982
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars