IL-10 enhances IgE-mediated mast cell responses and is essential for the development of experimental food allergy in IL-10-deficient mice

IL-10 is a key pleiotropic cytokine that can both promote and curb Th2-dependent allergic responses. Herein we demonstrate a novel role for IL-10 in promoting mast cell expansion and the development of IgE-mediated food allergy. Oral ovalbumin challenge in sensitized BALB/c mice resulted in a robust...

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Pubblicato in:J Immunol
Autori principali: Polukort, Stephanie H., Rovatti, Jeffrey, Carlson, Logan, Thompson, Chelsea, Ser-Dolansky, Jennifer, Kinney, Shannon R. M., Schneider, Sallie S., Mathias, Clinton B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893936/
https://ncbi.nlm.nih.gov/pubmed/27183617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600066
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