Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little is known about their functions in mammals. Here we show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes traffickin...

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Udgivet i:Sci Rep
Main Authors: Wunderle, Lina, Knopf, Julia D., Kühnle, Nathalie, Morlé, Aymeric, Hehn, Beate, Adrain, Colin, Strisovsky, Kvido, Freeman, Matthew, Lemberg, Marius K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893610/
https://ncbi.nlm.nih.gov/pubmed/27264103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27342
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