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Effects of Carbidopa and Entacapone on the Metabolic Fate of the Norepinephrine Prodrug L-DOPS

BACKGROUND: L-threo-3,4-dihydroxyphenylserine (L-DOPS), a norepinephrine (NE) prodrug, is investigational for orthostatic hypotension, which occurs commonly in Parkinson’s disease. Adjunctive anti-parkinsonian drugs might interact with L-DOPS. We tested whether L-aromatic aminoacid decarboxylase inh...

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Bibliographic Details
Published in:J Clin Pharmacol
Main Authors: Goldstein, David S., Holmes, Courtney, Sewell, LaToya, Pechnik, Sandra, Kopin, Irwin J.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893306/
https://ncbi.nlm.nih.gov/pubmed/20220040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270010363476
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