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Contamination of the Norepinephrine Prodrug Droxidopa by Dihydroxyphenylacetaldehyde
BACKGROUND: l-Threo-3,4-dihydroxyphenylserine (L-DOPS, droxidopa) is a norepinephrine (NE) prodrug under development to treat orthostatic hypotension. 3,4-Dihydroxyphenylacetaldehyde (DOPAL), an endogenous catecholaldehyde produced by enzymatic oxidative deamination of dopamine, is toxic to catechol...
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| Publié dans: | Clin Chem |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4578803/ https://ncbi.nlm.nih.gov/pubmed/20207766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2009.139709 |
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