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Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types

BACKGROUND: For many genes, RNA polymerase II stably pauses before transitioning to productive elongation. Although polymerase II pausing has been shown to be a mechanism for regulating transcriptional activation, the extent to which it is involved in control of mammalian gene expression and its rel...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Day, Daniel S., Zhang, Bing, Stevens, Sean M., Ferrari, Francesco, Larschan, Erica N., Park, Peter J., Pu, William T.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893286/
https://ncbi.nlm.nih.gov/pubmed/27259512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0984-2
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