Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk

OBJECTIVE: To discern presymptomatic changes in brain structure or function using advanced MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS). METHODS: T1-weighted, diffusion weighted and resting state functional MRI data were acquired at 3 T for 12 asymptomatic mutatio...

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Pubblicato in:J Neurol Neurosurg Psychiatry
Autori principali: Menke, Ricarda A L, Proudfoot, Malcolm, Wuu, Joanne, Andersen, Peter M, Talbot, Kevin, Benatar, Michael, Turner, Martin R
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2016
Soggetti:
Neurodegeneration
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893149/
https://ncbi.nlm.nih.gov/pubmed/26733601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2015-311945
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