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Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

OBJECTIVES: Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain. We determined the effects of a TrkA inhibitor (AR786) on pain beha...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Nwosu, Lilian N, Mapp, Paul I, Chapman, Victoria, Walsh, David A
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893148/
https://ncbi.nlm.nih.gov/pubmed/26286016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-207203
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