Role of EGF Receptor Ligands in TCDD-induced EGFR Down-regulation and Cellular Proliferation

In cultures of normal human epidermal keratinocytes (NHEKs), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces the expression of the epidermal growth factor receptor ligands transforming growth factor-α (TGF-α) and epiregulin (EREG). TCDD also down-regulates EGF receptors (EGFR), suggesting that de...

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Detalhes bibliográficos
Publicado no:Chem Biol Interact
Main Authors: Campion, Christina M, Carrion, Sandra Leon, Mamidanna, Gayatri, Sutter, Carrie Hayes, Sutter, Thomas R, Cole, Judith A
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892999/
https://ncbi.nlm.nih.gov/pubmed/27117977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2016.04.031
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