A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

Muscle contraction depends on release of Ca(2+) from the sarcoplasmic reticulum (SR) and reuptake by the Ca(2+)adenosine triphosphatase SERCA. We discovered a putative muscle-specific long noncoding RNA that encodes a peptide of 34 amino acids and that we named dwarf open reading frame (DWORF). DWOR...

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Publicado no:Science
Main Authors: Nelson, Benjamin R., Makarewich, Catherine A., Anderson, Douglas M., Winders, Benjamin R., Troupes, Constantine D., Wu, Fenfen, Reese, Austin L., McAnally, John R., Chen, Xiongwen, Kavalali, Ege T., Cannon, Stephen C., Houser, Steven R., Bassel-Duby, Rhonda, Olson, Eric N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892890/
https://ncbi.nlm.nih.gov/pubmed/26816378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad4076
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