Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. In human lung cancer, fibroblast growth factor 9 (FGF9), a high-affinity ligand for FGFR3, is overexpressed in 10% of primary resected non-small...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Yin, Yongjun, Ren, Xiaodi, Smith, Craig, Guo, Qianxu, Malabunga, Maria, Guernah, Ilhem, Zhang, Yiwei, Shen, Juqun, Sun, Haijun, Chehab, Nabil, Loizos, Nick, Ludwig, Dale L., Ornitz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892666/
https://ncbi.nlm.nih.gov/pubmed/27056048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.024760
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