X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.

RAS genes isolated from human tumors often have mutations at positions corresponding to amino acid 12 or 61 of the encoded protein (p21), while retroviral ras-encoded p21 contains substitutions at both positions 12 and 59. These mutant proteins are deficient in their GTP hydrolysis activity, and thi...

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Bibliografiska uppgifter
Huvudupphovsmän: Privé, G G, Milburn, M V, Tong, L, de Vos, A M, Yamaizumi, Z, Nishimura, S, Kim, S H
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1992
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC48926/
https://ncbi.nlm.nih.gov/pubmed/1565661
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