Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain.

Normal RAS proteins play a key role of molecular switch in the transduction of the growth signal from extracellular to intracellular space. The state of the switch is "on" when GTP is bound and "off" when GDP is bound to the protein. The crystal structure of a complex between a nonhydrolyzable GTP a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Brünger, A T, Milburn, M V, Tong, L, deVos, A M, Jancarik, J, Yamaizumi, Z, Nishimura, S, Ohtsuka, E, Kim, S H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54216/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2191303/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.12.4849
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