Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells

OBJECTIVE: PML is a rare and fatal demyelinating disease of the CNS caused by the human polyomavirus, JC virus (JCV), which occurs in AIDS patients and those on immunosuppressive monoclonal antibody therapies (mAbs). We sought to identify mechanisms that could stimulate reactivation of JCV in a cell...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Sariyer, Ilker Kudret, Sariyer, Rahsan, Otte, Jessica, Gordon, Jennifer
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892494/
https://ncbi.nlm.nih.gov/pubmed/27257867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156819
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