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Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells

OBJECTIVE: PML is a rare and fatal demyelinating disease of the CNS caused by the human polyomavirus, JC virus (JCV), which occurs in AIDS patients and those on immunosuppressive monoclonal antibody therapies (mAbs). We sought to identify mechanisms that could stimulate reactivation of JCV in a cell...

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Publicat a:PLoS One
Autors principals: Sariyer, Ilker Kudret, Sariyer, Rahsan, Otte, Jessica, Gordon, Jennifer
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892494/
https://ncbi.nlm.nih.gov/pubmed/27257867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156819
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