Inosine Triphosphatase Genetic Variants are Protective Against Anemia During Antiviral Therapy for HCV2/3 But Do Not Decrease Dose Reductions of RBV Or Increase SVR

Two functional variants in the inosine triphosphatase (ITPA) gene causing inosine triphos-phatase (ITPase) deficiency protect against ribavirin (RBV)-induced hemolytic anemia and the need for RBV dose reduction in patients with genotype 1 hepatitis C virus (HCV). No data are available for genotype 2...

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Publicado no:Hepatology
Main Authors: Thompson, Alexander J., Santoro, Rosanna, Piazzolla, Valeria, Clark, Paul J., Naggie, Susanna, Tillmann, Hans L., Patel, Keyur, Muir, Andrew J., Shianna, Kevin V., Mottola, Leonardo, Petruzzellis, Daniela, Romano, Mario, Sogari, Fernando, Facciorusso, Domenico, Goldstein, David B., McHutchison, John G., Mangia, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892367/
https://ncbi.nlm.nih.gov/pubmed/21274861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24068
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