Eosinophils contribute to intestinal inflammation via chemoattractant receptor-homologous molecule expressed on Th2 cells, CRTH2, in experimental Crohn’s disease

BACKGROUND AND AIMS: Prostaglandin (PG) D(2) activates two receptors, DP and CRTH2. Antagonism of CRTH2 has been shown to promote anti-allergic and anti-inflammatory effects. We investigated whether CRTH2 may play a role in Crohn’s disease (CD) focusing on eosinophils, which are largely present in t...

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Detalhes bibliográficos
Publicado no:J Crohns Colitis
Main Authors: Radnai, Balázs, Sturm, Eva M, Stančić, Angela, Jandl, Katharina, Labocha, Sandra, Ferreirós, Nerea, Grill, Magdalena, Hasenoehrl, Carina, Gorkiewicz, Gregor, Marsche, Gunther, Heinemann, Ákos, Högenauer, Christoph, Schicho, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892354/
https://ncbi.nlm.nih.gov/pubmed/26928963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjw061
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