Nmnat1 protects neuronal function without altering phospho‐tau pathology in a mouse model of tauopathy

OBJECTIVE: The nicotinamide‐nucleotide adenylyltransferase protein Nmnat1 is a potent inhibitor of axonal degeneration in models of acute axonal injury. Hyperphosphorylation and aggregation of the microtubule‐associated protein Tau are associated with neurodegeneration in Alzheimer's Disease an...

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Bibliografische gegevens
Gepubliceerd in:Ann Clin Transl Neurol
Hoofdauteurs: Musiek, Erik S., Xiong, David D., Patel, Tirth, Sasaki, Yo, Wang, Yinong, Bauer, Adam Q., Singh, Risham, Finn, Samantha L., Culver, Joseph P., Milbrandt, Jeffrey, Holtzman, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891997/
https://ncbi.nlm.nih.gov/pubmed/27547771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.308
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