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Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage
The critical cellular hydride donor NADPH is produced through various means, including the oxidative pentose phosphate pathway (oxPPP), folate metabolism and malic enzyme. In growing cells, it is efficient to produce NADPH via the oxPPP and folate metabolism, which also make nucleotide precursors. I...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891982/ https://ncbi.nlm.nih.gov/pubmed/26999781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2047 |
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