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Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice
Invariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, iNKT cells express T cell antigen receptors (TCRs) comprising a unique TCRα rearrangement between the Trav11 and Traj18 g...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891675/ https://ncbi.nlm.nih.gov/pubmed/27256918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27375 |
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