Isoflurane attenuates lipopolysaccharide-induced acute lung injury by inhibiting ROS-mediated NLRP3 inflammasome activation

Nucleotide-binding domains and leucine-rich repeat (NLR) pyrin domains containing 3 (NLRP3) inflammasome are highly involved in the pathogenesis of acute lung injury (ALI) wherein alveolar macrophages (AMs) play a crucial role. Isoflurane (ISO) has been shown to attenuate ALI. However, the inhibitor...

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Vydáno v:Am J Transl Res
Hlavní autoři: Yin, Ning, Peng, Zhendan, Li, Bin, Xia, Jiangyan, Wang, Zhen, Yuan, Jing, Fang, Lei, Lu, Xinjiang
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891417/
https://ncbi.nlm.nih.gov/pubmed/27347312
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