eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants

Activation of eIF4B correlates with Abl-mediated cellular transformation, but the precise mechanisms are largely unknown. Here we show that eIF4B is a convergent substrate of JAK/STAT/Pim and PI3K/Akt/mTOR pathways in Abl transformants. Both pathways phosphorylated eIF4B in Abl-transformed cells, an...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Chen, Ke, Yang, Jianling, Li, Jianning, Wang, Xuefei, Chen, Yuhai, Huang, Shile, Chen, Ji-Long
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891105/
https://ncbi.nlm.nih.gov/pubmed/26848623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7164
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