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Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization
Engineered variants of rebeccamycin halogenase were used to selectively halogenate a number of biologically active aromatic compounds. Subsequent Pd-catalyzed cross-coupling reactions on the crude extracts of these reactions were used to install aryl, amine, and ether substituents at the halogenatio...
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| Publicado en: | ACS Catal |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4890977/ https://ncbi.nlm.nih.gov/pubmed/27274902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.5b02558 |
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