NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD pathology. In AD brains, NMNAT2 mRNA and protein...

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Bibliografski detalji
Izdano u:PLoS Biol
Glavni autori: Ali, Yousuf O., Allen, Hunter M., Yu, Lei, Li-Kroeger, David, Bakhshizadehmahmoudi, Dena, Hatcher, Asante, McCabe, Cristin, Xu, Jishu, Bjorklund, Nicole, Taglialatela, Giulio, Bennett, David A., De Jager, Philip L., Shulman, Joshua M., Bellen, Hugo J., Lu, Hui-Chen
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890852/
https://ncbi.nlm.nih.gov/pubmed/27254664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002472
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