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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD pathology. In AD brains, NMNAT2 mRNA and protein...
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| Publicado no: | PLoS Biol |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4890852/ https://ncbi.nlm.nih.gov/pubmed/27254664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002472 |
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