Modeling and Re-Engineering of Azotobacter vinelandii Alginate Lyase to Enhance Its Catalytic Efficiency for Accelerating Biofilm Degradation

Alginate is known to prevent elimination of Pseudomonas aeruginosa biofilms. Alginate lyase (AlgL) might therefore facilitate treatment of Pseudomonas aeruginosa-infected cystic fibrosis patients. However, the catalytic activity of wild-type AlgL is not sufficiently high. Therefore, molecular modeli...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Jang, Chul Ho, Piao, Yu Lan, Huang, Xiaoqin, Yoon, Eun Jeong, Park, So Hee, Lee, Kyoung, Zhan, Chang-Guo, Cho, Hoon
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890793/
https://ncbi.nlm.nih.gov/pubmed/27253324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156197
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