3BNC117 a Broadly Neutralizing Antibody Suppresses Viremia in HIV-1-Infected Humans

HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineffective in pre-clinical and clinical settings and was therefore abandoned(1–3). However, recently developed single cell based antibody cloning methods have uncovered a new generation of far more potent b...

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Veröffentlicht in:Nature
Hauptverfasser: Caskey, Marina, Klein, Florian, Lorenzi, Julio C. C., Seaman, Michael S., West, Anthony P., Buckley, Noreen, Kremer, Gisela, Nogueira, Lilian, Braunschweig, Malte, Scheid, Johannes F., Horwitz, Joshua A., Shimeliovich, Irina, Ben Avraham-Shulman, Sivan, Witmer-Pack, Maggi, Platten, Martin, Lehmann, Clara, Burke, Leah A., Hawthorne, Thomas, Gorelick, Robert J., Walker, Bruce D., Keler, Tibor, Gulick, Roy M., Fätkenheuer, Gerd, Schlesinger, Sarah J., Nussenzweig, Michel C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890714/
https://ncbi.nlm.nih.gov/pubmed/25855300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14411
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