DNA CLEAVAGE AND DETECTION OF DNA RADICALS FORMED FROM HYDRALAZINE AND COPPER (II) BY ESR AND IMMUNO-SPIN TRAPPING

Metal ion-catalyzed oxidation of hydrazine and its derivatives leads to the formation of the hydrazyl radical and subsequently to oxy-radicals in the presence of molecular oxygen. Here we have examined the role of Cu(2+)-catalyzed oxidation of hydralazine in the induction of DNA damage. Neither 5, 5...

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Vydáno v:Chem Res Toxicol
Hlavní autoři: Sinha, Birandra K., Leinisch, Fabian, Bhattacharjee, Suchandra, Mason, Ronald P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890473/
https://ncbi.nlm.nih.gov/pubmed/24502259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500011m
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