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Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake

HIV-1 Tat plays an important role in HIV-associated neurocognitive disorders (HAND) by disrupting neurotransmission including dopamine uptake by human dopamine transporter (hDAT). Previous studies have demonstrated that HIV-1 Tat directly binds to hDAT and some amino-acid mutations that attenuate th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yuan, Yaxia, Quizon, Pamela M., Sun, Wei-Lun, Yao, Jianzhuang, Zhu, Jun, Zhan, Chang-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890318/
https://ncbi.nlm.nih.gov/pubmed/27250920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27314
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