How topoisomerase IV can efficiently unknot and decatenate negatively supercoiled DNA molecules without causing their torsional relaxation

Freshly replicated DNA molecules initially form multiply interlinked right-handed catenanes. In bacteria, these catenated molecules become supercoiled by DNA gyrase before they undergo a complete decatenation by topoisomerase IV (Topo IV). Topo IV is also involved in the unknotting of supercoiled DN...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Rawdon, Eric J., Dorier, Julien, Racko, Dusan, Millett, Kenneth C., Stasiak, Andrzej
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Computational Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889953/
https://ncbi.nlm.nih.gov/pubmed/27106058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw311
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