Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance

Background: The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) pump is an important component of the Ca(2+)-clock pacemaker mechanism that provides robustness and flexibility to sinus node pacemaking. We have developed transgenic mice with reduced cardiac SERCA2 abundance (Serca2 KO) as a model for i...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Logantha, Sunil Jit R. J., Stokke, Mathis K., Atkinson, Andrew J., Kharche, Sanjay R., Parveen, Sajida, Saeed, Yawer, Sjaastad, Ivar, Sejersted, Ole M., Dobrzynski, Halina
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889599/
https://ncbi.nlm.nih.gov/pubmed/27313537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00197
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