Transcriptional Profiling Suggests That Nevirapine and Ritonavir Cause Drug Induced Liver Injury Through Distinct Mechanisms in Primary Human Hepatocytes

Drug induced liver injury (DILI), a major cause of pre- and post-approval failure, is challenging to predict pre-clinically. Predicting DILI is challenging due to varied underlying direct and indirect mechanisms. Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) and Ritonavir, a p...

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Опубликовано в: :Chem Biol Interact
Главные авторы: Ylva, Terelius, Figler, Robert A, Svetlana, Marukian, Collado, Maria S, Lawson, Mark J, Mackey, Aaron J, David, Manka, Qualls, Charles W, Blackman, Brett R, Wamhoff, Brian R, Ajit, Dash
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889565/
https://ncbi.nlm.nih.gov/pubmed/26626330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2015.11.023
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