Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) resulting from a breakdown in peripheral immune tolerance. Although a beneficial role of natural killer (NK)-cell immune-regulatory function has been proposed, it still needs to be elucidated whe...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Gross, Catharina C., Schulte-Mecklenbeck, Andreas, Rünzi, Anna, Kuhlmann, Tanja, Posevitz-Fejfár, Anita, Schwab, Nicholas, Schneider-Hohendorf, Tilman, Herich, Sebastian, Held, Kathrin, Konjević, Matea, Hartwig, Marvin, Dornmair, Klaus, Hohlfeld, Reinhard, Ziemssen, Tjalf, Klotz, Luisa, Meuth, Sven G., Wiendl, Heinz
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889377/
https://ncbi.nlm.nih.gov/pubmed/27162345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524924113
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