Immune Cell Profiling During Switching from Natalizumab to Fingolimod Reveals Differential Effects on Systemic Immune-Regulatory Networks and on Trafficking of Non-T Cell Populations into the Cerebrospinal Fluid—Results from the ToFingo Successor Study

Leukocyte sequestration is an established therapeutic concept in multiple sclerosis (MS) as represented by the trafficking drugs natalizumab (NAT) and fingolimod (FTY). However, the precise consequences of targeting immune cell trafficking for immunoregulatory network functions are only incompletely...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lohmann, Lisa, Janoschka, Claudia, Schulte-Mecklenbeck, Andreas, Klinsing, Svenja, Kirstein, Lucienne, Hanning, Uta, Wirth, Timo, Schneider-Hohendorf, Tilman, Schwab, Nicholas, Gross, Catharina C., Eveslage, Maria, Meuth, Sven G., Wiendl, Heinz, Klotz, Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052886/
https://ncbi.nlm.nih.gov/pubmed/30050529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01560
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