Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling

BACKGROUND: Ascending thoracic aortic aneurysm (ATAA) is driven by angiotensin II (AngII) and contributes to the development of left ventricular (LV) remodeling through aortoventricular coupling. We previously showed that locally available leptin augments AngII‐induced abdominal aortic aneurysms in...

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Foilsithe in:J Am Heart Assoc
Main Authors: Ben‐Zvi, Danny, Savion, Naphtali, Kolodgie, Frank, Simon, Amos, Fisch, Sudeshna, Schäfer, Katrin, Bachner‐Hinenzon, Noa, Cao, Xin, Gertler, Arieh, Solomon, Gili, Kachel, Erez, Raanani, Ehud, Lavee, Jacob, Kotev Emeth, Shlomo, Virmani, Renu, Schoen, Frederick J., Schneiderman, Jacob
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2016
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889208/
https://ncbi.nlm.nih.gov/pubmed/27143353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003474
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