Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling

BACKGROUND: Ascending thoracic aortic aneurysm (ATAA) is driven by angiotensin II (AngII) and contributes to the development of left ventricular (LV) remodeling through aortoventricular coupling. We previously showed that locally available leptin augments AngII‐induced abdominal aortic aneurysms in...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Ben‐Zvi, Danny, Savion, Naphtali, Kolodgie, Frank, Simon, Amos, Fisch, Sudeshna, Schäfer, Katrin, Bachner‐Hinenzon, Noa, Cao, Xin, Gertler, Arieh, Solomon, Gili, Kachel, Erez, Raanani, Ehud, Lavee, Jacob, Kotev Emeth, Shlomo, Virmani, Renu, Schoen, Frederick J., Schneiderman, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889208/
https://ncbi.nlm.nih.gov/pubmed/27143353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003474
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