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The Role of MDM2 Amplification and Overexpression in Tumorigenesis
Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53, playing a key role in controlling its transcriptional activity, protein stability, and nuclear localization. MDM2 expression is up-regulated in numerous cancers, resulting in a loss of p53-dependent activities...
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| Veröffentlicht in: | Cold Spring Harb Perspect Med |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4888815/ https://ncbi.nlm.nih.gov/pubmed/27194168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026336 |
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