Oxidized glutathione (GSSG) inhibits epithelial sodium channel activity in primary alveolar epithelial cells

Amiloride-sensitive epithelial Na(+) channels (ENaC) regulate fluid balance in the alveoli and are regulated by oxidative stress. Since glutathione (GSH) is the predominant antioxidant in the lungs, we proposed that changes in glutathione redox potential (E(h)) would alter cell signaling and have an...

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Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Downs, Charles A., Kreiner, Lisa, Zhao, Xing-Ming, Trac, Phi, Johnson, Nicholle M., Hansen, Jason M., Brown, Lou Ann, Helms, My N.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888545/
https://ncbi.nlm.nih.gov/pubmed/25713321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00213.2014
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