Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

BACKGROUND: The nuclear hormone receptor RORγ regulates transcriptional genes involved in the production of the pro-inflammatory interleukin IL-17 which has been linked to autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. This transcriptional activi...

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Detalhes bibliográficos
Publicado no:BMC Struct Biol
Main Authors: Marcotte, Douglas J., Liu, YuTing, Little, Kevin, Jones, John H., Powell, Noel A., Wildes, Craig P., Silvian, Laura F., Chodaparambil, Jayanth V.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888278/
https://ncbi.nlm.nih.gov/pubmed/27246200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-016-0059-3
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