Vaccinia virus recombinants expressing chimeric proteins of human immunodeficiency virus and gamma interferon are attenuated for nude mice.

We have developed a method for attenuating vaccinia virus recombinants by expressing a fusion protein of a lymphokine and an immunogen. Chimeric genes were constructed that coded for gamma interferon (IFN-gamma) and structural proteins of the human immunodeficiency virus type 1 (HIV-1). In this stud...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Giavedoni, L D, Jones, L, Gardner, M B, Gibson, H L, Ng, C T, Barr, P J, Yilma, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48877/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1565633/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.8.3409
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