Asymmetric dimethylarginine (ADMA) elevation and arginase up‐regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans

KEY POINTS: The presence of insulin resistance (IR) is determinant for endothelial dysfunction associated with obesity. Although recent studies have implicated the involvement of mitochondrial superoxide and inflammation in the defective nitric oxide (NO)‐mediated responses and subsequent endothelia...

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Detalles Bibliográficos
Publicado en:J Physiol
Autores principales: El Assar, Mariam, Angulo, Javier, Santos‐Ruiz, Marta, Ruiz de Adana, Juan Carlos, Pindado, María Luz, Sánchez‐Ferrer, Alberto, Hernández, Alberto, Rodríguez‐Mañas, Leocadio
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cardiovascular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887698/
https://ncbi.nlm.nih.gov/pubmed/26840628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271836
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