Asymmetric dimethylarginine (ADMA) elevation and arginase up‐regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans

KEY POINTS: The presence of insulin resistance (IR) is determinant for endothelial dysfunction associated with obesity. Although recent studies have implicated the involvement of mitochondrial superoxide and inflammation in the defective nitric oxide (NO)‐mediated responses and subsequent endothelia...

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Vydáno v:J Physiol
Hlavní autoři: El Assar, Mariam, Angulo, Javier, Santos‐Ruiz, Marta, Ruiz de Adana, Juan Carlos, Pindado, María Luz, Sánchez‐Ferrer, Alberto, Hernández, Alberto, Rodríguez‐Mañas, Leocadio
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887698/
https://ncbi.nlm.nih.gov/pubmed/26840628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271836
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