Protein Kinase C-δ Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells

Angiotensin-converting enzyme 2 (ACE2) degrades angiotensin (Ang) II to Ang-(1–7), and protects against diabetic renal injury. Soluble ACE2 fragments are shed from the proximal tubule, and appear at high levels in the urine with diabetes. High glucose-induced shedding of ACE2 from proximal tubular c...

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Udgivet i:Front Pharmacol
Main Authors: Xiao, Fengxia, Zimpelmann, Joseph, Burger, Dylan, Kennedy, Christopher, Hébert, Richard L., Burns, Kevin D.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887483/
https://ncbi.nlm.nih.gov/pubmed/27313531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00146
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