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Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.

The tumor suppressor gene APC was recently identified, and the cDNA was cloned from chromosome 5q21. Point mutations affecting APC are seen in the hereditary syndrome familial adenomatous polyposis, and point mutations in APC and a closely linked gene, MCC, as well as loss of heterozygosity involvin...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Boynton, R F, Blount, P L, Yin, J, Brown, V L, Huang, Y, Tong, Y, McDaniel, T, Newkirk, C, Resau, J H, Raskind, W H
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48872/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1565631/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.8.3385
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