Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis

Skin homeostasis is maintained by the continuous proliferation and differentiation of epidermal cells. The skin forms a strong but flexible barrier against microorganisms as well as physical and chemical insults; however, the physiological mechanisms that maintain this barrier are not fully understo...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Yasuda, Takuwa, Fukada, Toshiyuki, Nishida, Keigo, Nakayama, Manabu, Matsuda, Masashi, Miura, Ikuo, Dainichi, Teruki, Fukuda, Shinji, Kabashima, Kenji, Nakaoka, Shinji, Bin, Bum-Ho, Kubo, Masato, Ohno, Hiroshi, Hasegawa, Takanori, Ohara, Osamu, Koseki, Haruhiko, Wakana, Shigeharu, Yoshida, Hisahiro
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887165/
https://ncbi.nlm.nih.gov/pubmed/27111231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82887
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